Indicator Explainer
Sex Hormone-Binding Globulin
Sex hormone-binding globulin (402 aa, ~44 kDa) is encoded by the human SHBG gene. This protein is involved in steroid transport.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C17128. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-19. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Sex Hormone-Binding Globulin (C17128)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C17128. NCI definition, reproduced without modification under CC BY 4.0.
- Sex hormone-binding globulin increases lumbar fracture risk via bone density, inflammation, and insulin pathways: A Mendelian randomization study. — Medicine (Baltimore), 2026-10-01 (PMID 42826275; literature)
- Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia. — Int J Mol Sci, 2026-09-20 (PMID 42794813; literature)
- Do Androgens and Sex Hormone-Binding Globulin Mediate Sex Differences in the Risk of Stroke and Myocardial Infarction? The KORA Study. — J Am Heart Assoc, 2026-09-18 (PMID 42757908; literature)
- Association of serum creatinine-to-albumin ratio with hyperandrogenemia and low sex hormone-binding globulin in women of reproductive age: a cross-sectional analysis of NHANES 2013-2016. — Gynecol Endocrinol, 2026-10-17 (PMID 42892725; literature)
- Serum sex hormone and triglyceride-glucose index in postmenopausal women: A population-based study from NHANES. — Int J Gynaecol Obstet, 2026-10-29 (PMID 42954750; literature)
- Second-trimester Maternal Serum Insulin-like Growth Factor Binding Protein 4 to Sex Hormone-binding Globulin Ratio as a Predictor of Spontaneous Preterm Birth: A Prospective Observation Study from North India. — Ann Afr Med, 2026-10-23 (PMID 42925268; literature)