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Glossary Term
A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene. When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound.
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This gene plays a role in DNA repair and regulation of transcription.
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This gene is involved in calcium-independent cellular adhesion and in the regulation of immune responses.
Glossary Term
Changes in the regulation of the expression of gene activity without alteration of genetic structure.
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This gene plays a role in cellular proliferation and is involved in the oncogenic process through amplification and/or overexpression in several cancers.
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This gene is involved in signal transduction pathways that result in cellular proliferation or differentiation. The gene has also been associated with numerous cancers.
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This gene is involved in neuronal development and plays a role in receptor tyrosine kinase signal transduction that regulates cellular proliferation and differentiation.
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This gene is involved in nucleotide excision repair and corrects sensitivity to UV radiation and defective nucleotide excision repair in xeroderma pigmentosum cells of complementation group D.
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This gene plays a regulatory role in transcription, cellular maintenance and hematopoiesis.
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This gene is involved in ligand-activated transcriptional activity.
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This gene plays a regulatory role in transcription and in matrix metalloproteinase activity.
Glossary Term
The sequences of a gene that are present in the final, mature, spliced messenger RNA molecule from that gene.
