Indicator Explainer

Scl-70 Antibody

An anti-nuclear autoantibody that recognizes a 70 kDa fragment of DNA topoisomerase 1. It is associated with scleroderma.

Reviewed 2026-10-20
Read this first

This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.

When it is tested

Source: National Cancer Institute, NCI Thesaurus 26.09d, C122770. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.

Reading results

Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.

Also Known As

Anti-Scl 70Anti-Scl 70 AntibodyAnti-Scl-70Anti-Scl-70 AntibodyAnti-Topoisomerase 1Anti-Topoisomerase 1 AntibodyAnti-Topoisomerase IAnti-Topoisomerase I AntibodyScl 70 AntibodyScl-70 AntibodyTopoisomerase 1 AntibodyTopoisomerase I Antibody