Indicator Explainer
Scl-70 Antibody
An anti-nuclear autoantibody that recognizes a 70 kDa fragment of DNA topoisomerase 1. It is associated with scleroderma.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C122770. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Scl-70 Antibody (C122770)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C122770. NCI definition, reproduced without modification under CC BY 4.0.
- Antiphospholipid Syndrome Coexisting With Evans Syndrome and SCL-70 Antibody Positivity: A Case Report. — Clin Case Rep, 2025-12-29 (PMID 41473885; literature)
- A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity. — Clin Lab, 2025-05-01 (PMID 40387758; literature)