Indicator Explainer
IgE
An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C567. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
Related Tests
Tests that measure or involve this indicator.
References
- NCI Thesaurus 26.09d — IgE (C567)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C567. NCI definition, reproduced without modification under CC BY 4.0.
- Who fails the egg ladder? Predictors of reactions and clinical outcomes with individualized entry-step selection in 197 children with IgE-mediated egg allergy. — Eur J Pediatr, 2026-10-09 (PMID 42855656; literature)
- Autoimmune Hemolytic Anemia in a Child with DOCK8-Deficient Hyper-IgE Syndrome. — Indian J Pediatr, 2026-10-09 (PMID 42853550; literature)
- Lactiplantibacillus Plantarum CKDB008 and Lacticaseibacillus Rhamnosus LDTM7511 Attenuate Visceral Hypersensitivity and Suppress Serum IgE in an Acetic Acid-Induced IBS-Like Rat Model. — Probiotics Antimicrob Proteins, 2026-10-09 (PMID 42853311; literature)
- Clinical and Immunological Determinants of Time to Open Oral Food Challenge-Confirmed Tolerance in Children With IgE-Mediated Food Allergy: A Retrospective Cohort Study. — Int Arch Allergy Immunol, 2026-10-07 (PMID 42842533; literature)
- Nasal Secretion Der p-Specific IgE as a Potential Non-Invasive Diagnostic Biomarker for House Dust Mite-Related Allergic Rhinitis: A Single-Center Cross-Sectional Diagnostic-Accuracy Study. — J Asthma Allergy, 2026-10-10 (PMID 42877264; literature)
- A rapid point-of-care detection system for OVA-specific IgG and IgE utilizing a rotational SlipChip. — Lab Chip, 2026-10-20 (PMID 42900462; literature)
- Identification of a Candidate IgE-Binding Maize Protein in a Patient With Corn-Dependent Exercise-Induced Anaphylaxis: A Case Report. — Case Reports Immunol, 2026-10-19 (PMID 42898784; literature)
- IgE-Binding Components in Fungi and Parasites: From Infection Severity to Allergy and Allergy Protection: An EAACI Position Paper. — Allergy, 2026-10-28 (PMID 42951336; literature)
- Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm. — Sci Signal, 2026-10-27 (PMID 42945328; literature)