Indicator Explainer
Complement C3
Complement C3 (1663 aa, ~187 kDa) is encoded by the human C3 gene. This protein plays a role in complement-mediated immunity.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C21527. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Complement C3 (C21527)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C21527. NCI definition, reproduced without modification under CC BY 4.0.
- Complement C3 in the silica nanoparticles protein corona promotes macrophage M1 polarization and subacute pulmonary fibrotic remodeling. — Environ Pollut, 2026-10-03 (PMID 42829097; literature)
- Corrigendum to "Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis." Kidney International 2025;108:1158-1169. — Kidney Int, 2026-10-01 (PMID 42760012; literature)
- The relationship between autoantibody and complement levels in the sera of patients with systemic lupus erythematosus. — Clin Immunol, 2026-09-25 (PMID 42790660; literature)
- Host C3 complement restricts bovine coronavirus infection in vitro via virus-induced IL-1β signaling. — Vet Immunol Immunopathol, 2026-09-12 (PMID 42735537; literature)