Glossary Term
Histone
Definition
Major protein component of chromatin. Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein. The various classes are now termed H1, H2A, H2B, H3, and H4. In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes. The histones in the octamer complex are also known as the core histones. The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C16687. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
References
- NCI Thesaurus 26.09d — Histone (C16687)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C16687. NCI definition, reproduced without modification under CC BY 4.0.
- IL-1β/IL-6 inflammatory crosstalk drives DNA methylation and histone remodeling associated with cytokine induced senescence in luminal breast cancer. — Inflamm Res, 2026-10-17 (PMID 42892641; literature)
- Exploring the role of histone deacetylases and histone deacetylase inhibitors in obesity and emerging evidence from Anorexia Nervosa. — Pharmacol Res, 2026-10-16 (PMID 42887616; literature)
- RCCD1-JMJD5 coordinate histone demethylation to promote platinum resistance in non-small cell lung cancer via FN1-mediated epithelial-mesenchymal transition. — Mol Biomed, 2026-10-21 (PMID 42905309; literature)
- Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. — Plant Cell Environ, 2026-10-20 (PMID 42902853; literature)
- Schaftoside from galgeuntang as a multi-target class I histone deacetylase inhibitor: Integrated molecular docking, dynamics, and systems pharmacology analysis. — Comput Biol Chem, 2026-10-23 (PMID 42925699; literature)
- Histone deacetylase 6 (HDAC6)-mediated α-tubulin (K40) deacetylation and microtubule destabilization disrupt autophagosome-lysosome fusion in PBDE-47-induced neurotoxicity. — Arch Toxicol, 2026-10-23 (PMID 42919942; literature)
- Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation. — Adv Sci (Weinh), 2026-10-25 (PMID 42928409; literature)
- Inhibition of histone deacetylase 3 alleviates lithocholic acid-induced intrahepatic cholestasis by enhancing expression of bile acid and lipid homeostasis-related genes. — Acta Pharmacol Sin, 2026-10-23 (PMID 42919897; literature)
- Reader protein recognition of histone post-translational modifications: Role of aromatic interactions and cooperativity. — Curr Opin Chem Biol, 2026-10-28 (PMID 42950692; literature)
- Integrative single-cell transcriptomic and metabolic profiling reveals lactate-driven glycolytic reprogramming and histone lactylation in colorectal cancer liver metastasis. — J Pathol, 2026-10-27 (PMID 42947461; literature)