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Glossary Term
Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
Glossary Term
A type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen.
Glossary Term
The nonstaining primary constriction of a chromosome which is the point of attachment of the spindle fiber; provides the mechanism of chromosome movement during cell division; the centromere divides the chromosome into two arms, and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric).
Glossary Term
The process by which a person demonstrates specific knowledge, skills, or abilities in the view of a certifying body. Similarly, the process by which a product or process can achieve certification indicating its suitability for a specific purpose.
Glossary Term
A specific sequence of three adjacent bases on a strand of DNA or RNA that provides genetic code information for a particular amino acid.
Glossary Term
A WHO procedure that time-limits the listing of diagnostics (and other health products) for use in public-health emergencies when full prequalification is not yet available.
Glossary Term
A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene. When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound.
Glossary Term
Metabolomics is the study of the biological metabolic profile of a cellular specimen in a specific environment at an isolated timepoint. This discipline depicts the physiological states of cells and organisms by focusing on carbohydrates, lipids, and other metabolites. Several analytical techniques are utilized to quantify the metabolic content of specimens such as mass spectrometry and electrophoretic applications.
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Genomic instability associated with the presence of hypermutability in specific genetic marker regions resulting from defective DNA mismatch repair.
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A test result that indicates that a specific disease, condition, or attribute being assessed is not present.
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An organisation designated by an EU member state to assess the conformity of products — including in vitro diagnostics — against applicable regulations before CE marking can be affixed.
Glossary Term
Laboratory procedure in which single stranded nucleic acids are allowed to interact so that complexes, or hybrids, are formed by molecules with sufficiently similar, complementary sequences. By this means the degree of sequence identity can be assessed and specific sequences detected. (From Biology-online)
