Indicadores
BRCA2 Gene
This gene is involved in cell cycle control, DNA repair and the maintenance of genomic stability. It also plays a role in the proliferation of embryonic cells.
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Indicadores
This gene is involved in cell cycle control, DNA repair and the maintenance of genomic stability. It also plays a role in the proliferation of embryonic cells.
Indicadores
This gene is involved in T cell activation and proliferation.
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This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
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This gene plays an inhibitory role in cell survival and proliferation.
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This gene plays a role in cellular proliferation and is involved in the oncogenic process through amplification and/or overexpression in several cancers.
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This gene is involved in signal transduction pathways that result in cellular proliferation or differentiation. The gene has also been associated with numerous cancers.
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This gene is involved in neuronal development and plays a role in receptor tyrosine kinase signal transduction that regulates cellular proliferation and differentiation.
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A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)
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Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune responses.
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A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.
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Interleukin-4 (153 aa, ~17 kDa) is encoded by the human IL4 gene. This protein is involved in the regulation of the expression of class II MHC molecules, Fc receptors and cell surface-bound immunoglobulins.
Indicadores
This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.