Glossary Term
Adjusted R Squared
The goodness of fit statistic for the terminal elimination phase, adjusted for the number of time points used in the estimation of Lambda z.
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Glossary Term
The goodness of fit statistic for the terminal elimination phase, adjusted for the number of time points used in the estimation of Lambda z.
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A starting point to which things may be compared.
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The nonstaining primary constriction of a chromosome which is the point of attachment of the spindle fiber; provides the mechanism of chromosome movement during cell division; the centromere divides the chromosome into two arms, and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric).
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A study in which participants are examined once for a characteristic, such as disease, at a single point in time.
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Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
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A US pathway in which a device maker demonstrates substantial equivalence to a legally marketed predicate. For IVD test kits, 510(k) clearance documents intended use and analytical/clinical support; it is distinct from CLIA waiver, which concerns point-of-care operation settings.
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A point mutation occurring within the protein-coding region of a gene, and which codes for a different amino acid than expected.
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A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein.
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Any of the 99 numbered points that divide an ordered set of scores into 100 parts each of which contains one-hundredth of the total.
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A small-scale mutation in which a single nucleotide is exchanged for another. Mutagenic chemicals and mistakes in DNA replication may result in point mutations.
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One of the three possible ways of reading a nucleotide sequence. As the genetic code is read in nonoverlapping triplets (codons) there are three possible ways of translating a sequence of nucleotides into a protein, each with a different starting point.
Glossary Term
Complementary precision measures: repeatability is variation under the same conditions (same operator, equipment, short interval); reproducibility is variation across conditions — different days, operators, lots, or laboratories.