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A heterodimeric or heterotetrameric protein complex comprised of protein S100A8 and protein S100A9. This complex is expressed in the cytosol of neutrophils and macrophages and plays a role in multiple host defense related processes including immunomodulation, neutrophil chemotaxis and both antibacterial and antifungal responses.
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Growth/differentiation factor 15 (308 aa, ~34 kDa) is encoded by the human GDF15 gene. This protein plays a role in both tissue differentiation and signal transduction.
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Interferon gamma (166 aa, ~19 kDa) is encoded by the human IFNG gene. This protein is involved in antiviral activity, macrophage activation, antiproliferative activity and immunopotentiation.
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Interleukin-1 beta (269 aa, ~31 kDa) is encoded by the human IL1B gene. This protein is involved in the macrophage-dependent inflammatory response.
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Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.