Technology
LC/MS is a hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
Diagnostic Methods
Technology
An analytical technique wherein liquid chromatography is coupled to tandem mass spectrometry in order to separate, identify, and quantify substances in a sample.
Diagnostic Methods
Technology
A type of nucleic acid amplification test in which sample DNA is exposed to a single temperature in the presence of multiple sets of primers and a polymerase with replication and high strand displacement activity. This test negates the need for thermal cyclers and may be a low cost alternative to PCR.
Diagnostic Methods
Technology
An analysis done to detect monoallelic loss of genes or DNA regions in a diploid cell.
Diagnostic Methods
Technology
A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow of patients who are to undergo autologous bone marrow transplantation.
Diagnostic Methods
Technology
A flow cytometry technique that utilizes mass spectrometry to detect antibodies labeled with heavy metal ion tags that are bound to antigens of interest on single cells.
Diagnostic Methods
Technology
An analytical technique wherein ions are separated according to their ratio of charge to mass. From the mass spectrum produced, the atomic weight of the particle can be deduced.
Diagnostic Methods
Technology
An analysis of DNA or protein to detect the presence and/or location of methyl groups.
Diagnostic Methods
Technology
Analysis using microarray technology (e.g., cDNA arrays to see gene expression or protein microarrays to profile the pattern of proteins).
Diagnostic Methods
Technology
A laboratory method in which the tissue from a histology slide is dissected under a microscope to procure specific cells or cell populations.
Diagnostic Methods
Technology
A type of enzyme immunoassay that uses antigen-coated microparticles as a substrate for antibody binding.
Diagnostic Methods
Technology
A laboratory procedure to detect microsatellite instability.
Diagnostic Methods