Indicadores
CUL3 Gene
This gene plays a role in protein degradation and cell cycle arrest.
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Indicadores
This gene plays a role in protein degradation and cell cycle arrest.
Indicadores
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)
Indicadores
This gene plays a role in signal transduction, regulation of transcription and enhancement of apoptosis.
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This gene may play a role in RNA splicing and tumor suppression.
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This gene is involved in the RNA interference pathway.
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A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)
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This gene is involved in epigenetic control of gene expression.
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This gene plays a role in the negative regulation of transcription.
Indicadores
This gene plays a role in DNA repair and regulation of transcription.
Indicadores
This gene is involved in signal transduction pathways that result in cellular proliferation or differentiation. The gene has also been associated with numerous cancers.
Indicadores
This gene is involved in neuronal development and plays a role in receptor tyrosine kinase signal transduction that regulates cellular proliferation and differentiation.
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This gene is involved in nucleotide excision repair and corrects sensitivity to UV radiation and defective nucleotide excision repair in xeroderma pigmentosum cells of complementation group D.