Indicadores
RET Gene
This gene plays an essential role in neural crest development, cellular growth and differentiation. Mutations in the gene are associated with a variety of neoplasias and carcinomas.
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Indicadores
This gene plays an essential role in neural crest development, cellular growth and differentiation. Mutations in the gene are associated with a variety of neoplasias and carcinomas.
Indicadores
A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C.
Glossary Term
A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected.
Glossary Term
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though they will be transmitted during any mitosis within the individual. Somatic mutations may contribute to a broad variety of pathologies including cancer.
Glossary Term
Any mutation that occurs within the discrete sequences comprising the 5' or 3' splice sites of a gene that has a spliced message. Splice-site mutation may result in a deletion or insertion of extraneous amino acids in the gene product or a change in the reading frame of the spliced message.
Artículo
Research record from Curr Oncol, 2026-10-06. PMID 42930168.
Artículo
Research record from Clin Lab, 2026-10-01. PMID 42847947.
Artículo
Research record from Cancer Treat Res Commun, 2026-04-22. PMID 42172690.
Pruebas
A TP53 genetic test uses a sample of your blood, bone marrow, or tissue from a tumor to look for changes in the tumor protein 53 gene, or TP53 for short. Changes in your genes are also called gene variants or mutations.
Glossary Term
A relatively less common point mutation in which a purine is exchanged for a pyrimidine or a pyrimidine is exchanged for a purine.
Artículo
Research record from Diagn Cytopathol, 2026-07-16. PMID 42464567.