Indicadores
A protein complex comprised of one T-cell surface glycoprotein CD3 delta chain (CD3D), one T-cell surface glycoprotein CD3 gamma chain (CD3G) and two T-cell surface glycoprotein CD3 epsilon chains (CD3E). CD3D, CD3G and CD3E are transmembrane proteins with one extracellular immunoglobulin domain and one intracellular ITAM domain. The CD3 complex is a T-cell co-receptor that noncovalently associates with either the disulfide bound heterodimeric alpha/beta T-cell receptor (TCR) or gamma/delta TCR and two copies of the accessory protein, T-cell surface glycoprotein CD3 zeta chain (CD247), which is a transmembrane protein with three ITAM domains. The TCR moiety of the TCR-CD3 complex binds to MHC and processed antigens on antigen presenting cells, which triggers phosphorylation of and cellular propagation of the signal by CD247 and the CD3 complex.
Pruebas
A measurement of cellular CD69 expression present in a sample.
For professionals
Indicadores
This gene plays a role in cell-cell adhesion and loss of function contributes to the progression of many carcinomas.
Indicadores
This gene plays a role in the progression of the cell cycle.
Indicadores
This gene functions as a tumor suppressor and transcriptional regulator.
Glossary Term
A manufacturer declaration that an in vitro diagnostic complies with applicable EU legislation (the IVDR since May 2022). CE-IVD indicates regulatory conformance, not a statement of clinical superiority; buyers still review performance claims and intended use.
Regulatory Definitions
Pruebas
A laboratory blood test to measure carcinoembryonic antigen (CEA), a protein found in many types of cells, but is associated with tumors. Used as a tumor marker.
For professionals
Indicadores
This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
Glossary Term
A process where a rotating machine exposes a specimen to centrifugal force. This process can be used to remove moisture from a specimen, to subject an organism to increased gravitational forces, or to separate the components of heterogeneous mixtures based on density differences.
Extraction Methodology
Glossary Term
A machine that uses centrifugal force to separate heavier substances from lighter ones, for removing moisture, or for simulating gravitational effects.
Pcr Terms
Glossary Term
The nonstaining primary constriction of a chromosome which is the point of attachment of the spindle fiber; provides the mechanism of chromosome movement during cell division; the centromere divides the chromosome into two arms, and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric).
Pcr Terms
Pruebas
A measurement of centromere B antibodies present in a sample.
For professionals
