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Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.

Pcr Terms

Artículo

Doping Control Analysis of Methoxyflurane in Equine Plasma by Headspace Gas Chromatography-Tandem Mass Spectrometry.

Research record from Drug Test Anal, 2026-09-08. PMID 42710866.

Indicadores

Growth/Differentiation Factor 15

Growth/differentiation factor 15 (308 aa, ~34 kDa) is encoded by the human GDF15 gene. This protein plays a role in both tissue differentiation and signal transduction.

Artículo

High-throughput quantification of tacrolimus in whole blood by acoustic ejection mass spectrometry: analytical validation and comparative assessment against conventional LC-MS/MS for therapeutic drug monitoring.

Research record from Clin Chim Acta, 2026-03-26. PMID 41903863.

Artículo

HIV-1 APOBEC-context Mutations Detected by Next-Generation Sequencing in Plasma: Implications for Drug Resistance Interpretation.

Research record from J Infect Dis, 2026-09-01. PMID 42244370.

Artículo

Is targeted next generation sequencing for drug-resistant tuberculosis feasible in a high-burden setting: a qualitative study from Indonesia.

Research record from BMJ Open, 2026-08-11. PMID 42580827.

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