Indicadores
STAT3 Gene
This gene plays a role in signal transduction and activation of transcription. It is involved in regulation of both apoptosis and cell growth.
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Indicadores
This gene plays a role in signal transduction and activation of transcription. It is involved in regulation of both apoptosis and cell growth.
Pruebas
The determination of the amount of total tumor necrosis factor superfamily member 12 present in a sample.
Indicadores
This gene may play a role in the regulation of apoptosis.
Glossary Term
Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.