Indicadores
MEN1 Gene
This gene is involved in transcriptional regulation and has tumor suppressor activity.
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Indicadores
This gene is involved in transcriptional regulation and has tumor suppressor activity.
Indicadores
This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
Indicadores
This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Indicadores
This gene is involved in tumor suppression and mutations in this gene have been associated with several cancers and cancer related diseases.
Indicadores
A secreted antigen derived from two nearly identical cytoplasmic glycoproteins of the serpin family, serpin B3 (SCCA-1) and serpin B4 (SCCA-2). These proteins are specifically expressed in normal squamous epithelia and are present at elevated concentrations in the serum of subjects with squamous cell carcinoma and certain inflammatory and autoimmune diseases. This antigen was first described in squamous cell cervical carcinoma; it is currently used as a nonspecific tumor marker for the presence, staging and monitoring of the disease course for squamous cell carcinomas of the head and neck, cervix, esophagus, anus and lung.
Indicadores
Tumor-associated oncofetal glycoprotein 72 (TAG-72) is a high molecular weight (220-400 kD) complex expressed by a wide variety of human adenocarcinomas. This antigen is expressed by a majority of invasive ductal breast carcinomas, and most colon, pancreatic, gastric, esophageal, lung (non-small cell), ovarian and endometrial adenocarcinomas, and on normal secretory endometrium, but not on other normal tissues. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas or benign tumors. The monoclonal antibodies against TAG-72 have been widely employed for the immunohistochemical analysis of adenocarcinomas as well as for radioimmunoscintigraphy and radioimmunoguided surgery.
Indicadores
This gene plays a critical role in cell cycle regulation and has tumor suppressor activity.
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This gene plays a role in both transcriptional regulation and limb development.
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Tumor necrosis factor (233 aa, ~26 kDa) is encoded by the human TNF gene. This protein is involved in the induction of cytokine expression, the stimulation of cell proliferation and the positive regulation of cell differentiation.
Indicadores
Tumor necrosis factor receptor superfamily member 11B (401 aa, ~46 kDa) is encoded by the human TNFRSF11B gene. This protein plays a role in the negative regulation of both osteoblast differentiation and bone resorption.
Indicadores
This gene is involved in transcriptional repression and protein degradation.