Indicadores
A nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.
Glossary Term
EU Regulation 2017/746 governing in vitro diagnostics, which replaced the IVDD with stricter evidence, post-market surveillance, and reclassification rules. Products legacy-listed under the IVDD may still carry transitional timelines, so registration status should be verified per product and per market.
Regulatory Definitions
Artículo
Research record from J Clin Med, 2026-07-12. PMID 42513364.
Artículo
Research record from Indian J Med Microbiol, 2026-08-10. PMID 42575447.
Indicadores
A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.
Glossary Term
A PCR method that measures amplification as it happens using fluorescent reporters, so target quantity is estimated from the amplification curve rather than by post-run handling. qPCR is the workhorse format for viral load, pathogen detection, and GMO or food testing workflows.
Pcr Terms
Artículo
Research record from J Coll Physicians Surg Pak, 2026-03-01. PMID 41781826.
Artículo
Research record from Genes (Basel), 2026-06-22. PMID 42353884.
Artículo
Research record from NPJ Parkinsons Dis, 2026-03-04. PMID 41775741.
