Indicadores
Complement Component C9
Complement component C9 (559 aa, ~63 kDa) is encoded by the human C9 gene. This protein plays a role in complement-mediated bacterial cell lysis.
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Indicadores
Complement component C9 (559 aa, ~63 kDa) is encoded by the human C9 gene. This protein plays a role in complement-mediated bacterial cell lysis.
Indicadores
Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.
Indicadores
IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity. It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2.