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Glossary Term
Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
Indicadores
This gene is involved in signal transduction and apoptosis.
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This gene plays a role in several cellular processes related to cellular viability; including the cell cycle and apoptosis.
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This gene plays a role in both cell cycle arrest and the inhibition of apoptosis.
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This gene plays a role in apoptosis, cell growth, differentiation and proliferation.
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This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
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Neutrophil gelatinase-associated lipocalin (198 aa, ~23 kDa) is encoded by the human LCN2 gene. This protein may play a role in iron transport, apoptosis, and innate immunity.
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This gene is involved in second messenger signaling, apoptosis, cell growth and angiogenesis.
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This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression.
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This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
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The fat soluble vitamin retinol. Vitamin A binds to and activates retinoid receptors (RARs), thereby inducing cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis. Vitamin A plays an essential role in many physiologic processes, including proper functioning of the retina, growth and differentiation of target tissues, proper functioning of the reproductive organs, and modulation of immune function.
Indicadores
This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation of intercellular junctions.
