Indicadores
ESR1 Gene
This gene is involved in ligand-activated transcriptional activity.
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Indicadores
This gene is involved in ligand-activated transcriptional activity.
Indicadores
Growth/differentiation factor 15 (308 aa, ~34 kDa) is encoded by the human GDF15 gene. This protein plays a role in both tissue differentiation and signal transduction.
Indicadores
A physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.
Indicadores
Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)
Indicadores
Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains but Ig lambda light chains contain a variable and a constant region. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. During differentiation of an activated (lambda-type) antibody-producing B-cell, diversity in the lambda light chain V region arises from variable recombination of lambda V genes with lambda J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM 147220 and NCI)
Indicadores
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
Indicadores
A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.
Indicadores
This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.
Indicadores
This gene plays a role in both protein phosphorylation and signal transduction.
Indicadores
This gene plays a role in mediating cellular responses to growth factors, metabolic stimuli and mitogens.
Pruebas
The determination of the amount of paired box 5 protein in a biological specimen
Pruebas
A partial thromboplastin time (PTT) test uses a blood sample to measure the number of seconds it takes for your blood to clot . Normally, when you get a cut or injury that causes bleeding, many different types of proteins in your blood work together to make a clot to stop the bleeding. These proteins are called coagulation factors or clotting factors, and your liver makes most of them.