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Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.
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An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair.
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This gene is involved in both protein ubiquitination and the Wnt signaling pathway.
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This gene plays a role in transcriptional regulation and cytogenetic aberrations are associated with several leukemias.
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Sclerostin (213 aa, ~24 kDa) is encoded by the human SOST gene. This protein plays a role in the regulation of bone growth and Wnt signaling pathways.
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This gene is involved in the mitochondrial respiratory chain.
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This gene is involved in mitochondrial electron transport.
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Secretogranin-1 (677 aa, ~78 kDa) is encoded by the human CHGB gene. This protein may play a role in the synthesis of biologically active peptides.
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A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C.
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Serotransferrin (698 aa, ~77 kDa) is encoded by the human TF gene. This protein is involved in iron sequestration and transport.
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This gene may be involved in the modulation of protein SET activity.
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This gene is involved in epigenetic control of gene expression through histone methylation.
