Indicadores
The most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG1 core hinge sequence contains 15 amino acids and two interchain disulfide bonds. This subtype has high affinity for binding both Fc receptors and complement component C1q. IgG1 is the predominant antibody subclass that responds to antigens derived from both soluble and membrane proteins. Reduced levels of circulating IgG1 can indicate the presence of a variety of primary and secondary antibody deficiencies, which can result in hypogammaglobulinemia.
Indicadores
Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)
Indicadores
Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains but Ig lambda light chains contain a variable and a constant region. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. During differentiation of an activated (lambda-type) antibody-producing B-cell, diversity in the lambda light chain V region arises from variable recombination of lambda V genes with lambda J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM 147220 and NCI)
Pruebas
Clinical laboratory tests that examine antigen-antibody reactions in whole blood or its cellular and/or fluid components that may impact natural processes, such as fertility, and clinical procedures affected by tissue and blood compatibility, such as transplants and transfusions.
For professionals
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A measurement of the industrial mix antigen IgE antibody in a biological specimen.
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The determination of the amount of the Influenza B IgG antibody in a sample.
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The determination of the amount of insulin antibody in a biological specimen.
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The determination of the amount of islet cell cytoplasmic IgG antibody present in a sample.
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The determination of the amount of Japanese encephalitis virus antibody present in a sample.
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The determination of the amount of Jo-1 antibody present in a sample.
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The determination of the amount of keyhole limpet hemocyanin IgG antibody in a biological sample.
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The determination of the amount of Legionella pneumophila IgG and IgM antibody present in a sample.
For professionals
