Indicadores
Along with the immunoglobulin G3 subclass (IgG3), the IgG4 subtype makes up a minor part of circulating antibodies in healthy individuals. The IgG4 core hinge sequence contains 12 amino acids and two interchain disulfide bonds.This subtype has moderate affinity for binding Fc receptors and does not bind complement component C1q. The production of IgG4 can be stimulated following repeated or long-term exposure to antigen. Elevated levels are found in various diseases and infections and can be indicative of an fibroinflammatory syndrome known as IgG4-related disease.
Pruebas
Clinical laboratory tests that examine antigen-antibody reactions in whole blood or its cellular and/or fluid components that may impact natural processes, such as fertility, and clinical procedures affected by tissue and blood compatibility, such as transplants and transfusions.
For professionals
Pruebas
Laboratory test involving interaction of antigens with specific antibodies.
For professionals
Pruebas
The determination of the ratio of prostate cancer antigen 3 mRNA as compared to the total prostate specific antigen mRNA present in a sample. The measurement may be expressed as a ratio or percentage.
For professionals
Indicadores
Prostate-specific antigen — a prostate tissue protein whose blood level rises in prostate cancer and in common benign conditions.
Pruebas
An immunology test to measure for the presence of the Rh factor antigen in blood.
For professionals
Indicadores
Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.
Pruebas
The determination of the amount of Salsola tragus pollen antigen IgE antibody present in a sample.
For professionals
Pruebas
The determination of the amount of cancer antigen 125 present in a blood serum sample.
For professionals
Pruebas
The determination of the amount of carcinoembryonic antigen present in a serum sample.
For professionals
Indicadores
A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)
Pruebas
The determination of the amount of T-cell surface antigen T4/Leu-3 in a sample.
For professionals
