Tests
Ubiquitin-Like Protein ISG15 Measurement
The determination of the amount of ubiquitin-like protein ISG15 present in a sample.
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Tests
The determination of the amount of ubiquitin-like protein ISG15 present in a sample.
Indicators
This gene is involved in cellular growth regulation and is purported to have tumor suppression activity.
Indicators
This gene is involved in ubiquitin-dependent proteolysis and regulation of the G1-S cell cycle checkpoint.
Indicators
This gene is involved in ubiquitin-mediated protein degradation.
Glossary Term
Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.