Indicator Explainer
FBXW7 Gene
This gene is involved in ubiquitin-dependent proteolysis and regulation of the G1-S cell cycle checkpoint.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C20786. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — FBXW7 Gene (C20786)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C20786. NCI definition, reproduced without modification under CC BY 4.0.
- FBXW7 Gene Mutation and Expression in Colorectal Cancer (CRC): A Systematic Review from Molecular Mechanisms to Clinical Translation. — Int J Mol Sci, 2025-11-23 (PMID 41373479; literature)
- Prognostic value of FBXW7 tumor suppressor gene expression and mutations in patients with colorectal cancer: A meta-analysis. — Cancer Treat Res Commun, 2025-08-29 (PMID 40934648; literature)
- Case report: A novel FBXW7 gene variant causes global developmental delay. — Front Genet, 2024-09-19 (PMID 39364007; literature)
- Targeted variant prevalence of FBXW7 gene mutation in colorectal carcinoma propagation. The first systematic review and meta-analysis. — Heliyon, 2024-05-22 (PMID 38845996; literature)