Indicators
IgM
The major immunoglobulin secreted during a primary immune response. IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers.
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Indicators
The major immunoglobulin secreted during a primary immune response. IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers.
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Prostaglandin-H2 D-isomerase (190 aa, ~21 kDa) is encoded by the human PTGDS gene. This protein is involved in the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2).
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This gene is involved in RNA binding and processing.
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Serotransferrin (698 aa, ~77 kDa) is encoded by the human TF gene. This protein is involved in iron sequestration and transport.
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This gene may be involved in the modulation of protein SET activity.
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Sex hormone-binding globulin (402 aa, ~44 kDa) is encoded by the human SHBG gene. This protein is involved in steroid transport.
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A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)
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Transthyretin (147 aa, ~16 kDa) is encoded by the human TTR gene. This protein is involved in both the binding and transport of retinol and thyroxine.
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This gene is involved in RNA binding and pre-mRNA splicing.