Glossary Term
Gene Deletion
A deletion that results in the loss of a DNA segment encompassing an entire gene sequence.
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Glossary Term
A deletion that results in the loss of a DNA segment encompassing an entire gene sequence.
Glossary Term
Typically involves transcription of genetically encoded information into an intermediary message (messenger RNA) and subsequent translation into a functional protein.
Glossary Term
Any hybrid gene formed from two previously separate genes. Such fusions occur as a result of translocation, intersititial deletion or chromosomal inversion, and often result in gene products with functions different from the two fusion partners. Gene fusions are associated frequently with hematological cancers, sarcomas and prostate cancer.
Glossary Term
Genetic Variation consists of deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents.
Glossary Term
The complete genomic content of an organism, and possibly the full DNA sequence of that organism. It is contained in a set of chromosomes in eukaryotes, a single chromosome in bacteria, or a DNA or RNA molecule in viruses.
Glossary Term
The determination of the DNA sequence of an individual.
Indicators
A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Glossary Term
The n-th root of the multiple products of n values, as contrasted with the normally understood arithmetic mean.
Tests
The determination of the number of a sub-population of germinal center B-lymphocytes in a sample.
Glossary Term
Any mutation that appears in the gametes and which will therefore be transmitted to the progeny with some frequency.
Tests
The determination of the ratio of globulin compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.
Tests
A measurement of the glucose clearance in a sample.