Glossary Term
Gene Fusion
PCR TermsEN
Definition
Any hybrid gene formed from two previously separate genes. Such fusions occur as a result of translocation, intersititial deletion or chromosomal inversion, and often result in gene products with functions different from the two fusion partners. Gene fusions are associated frequently with hematological cancers, sarcomas and prostate cancer.
Extended Notes
Source: National Cancer Institute, NCI Thesaurus 26.09d, C20195. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Also Known As
Gene Fusion
References
- NCI Thesaurus 26.09d — Gene Fusion (C20195)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C20195. NCI definition, reproduced without modification under CC BY 4.0.
- Expanding the genetic landscape of seromucinous hamartoma: novel HMGA2::PHF14 gene fusion - a case report. — Virchows Arch, 2026-10-14 (PMID 42870126; literature)
- Intracranial Mesenchymal Tumor with FET-CREB Gene Fusion: A Case Report of Late Recurrence. — Onco Targets Ther, 2026-09-29 (PMID 42829708; literature)
- [Intraosseous sarcoma with osteoid production and evidence of an EWSR1::SSX1 gene fusion]. — Pathologie (Heidelb), 2026-10-28 (PMID 42955348; literature)