National Cancer Institute (source definition)
Single Cell RNA Sequencing
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an amplified nucleotide sample that was derived from a single cell.
Review and references
Automated source check (NCI definition)
2026-10-19
2026-10-31
professional use
References
- NCI Thesaurus 26.09d — Single Cell RNA Sequencing (C171152)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C171152. NCI definition, reproduced without modification under CC BY 4.0.
- Single-cell RNA sequencing reveals vascular heterogeneity and cell-cell communication remodeling in the glioma blood-tumor barrier. — Brain Res, 2026-10-09 (PMID 42854890; literature)
- scCADI: Cell-Aware Diffusion Model for Single-Cell RNA-seq Imputation. — Interdiscip Sci, 2026-10-09 (PMID 42853537; literature)
- Integrative genotype-environment association and single-cell transcriptomic analyses identify candidate mechanisms of environmental adaptation in pigs. — Mol Biol Evol, 2026-10-09 (PMID 42851070; literature)
- Integrated single-cell and metabolomic profiling identifies ovarian metabolic differences and endothelial heterogeneity associated with litter-size variation in Hu sheep. — J Anim Sci Biotechnol, 2026-10-09 (PMID 42850629; literature)
- Single-cell insights into obesity: cellular mechanisms across metabolic organs. — J Nutr, 2026-10-15 (PMID 42880715; literature)
- From Single-Cell Sequencing Data Analysis to Functional Validation: XCL1 is Associated with Glycolytic Metabolism in Oral Squamous Cell Carcinoma. — J Stomatol Oral Maxillofac Surg, 2026-10-15 (PMID 42880453; literature)
- Single-Cell Multiomics Integration Reveals Cell Trajectories and Regulatory Networks in Breast Cancer Progression. — Int J Genomics, 2026-10-16 (PMID 42891116; literature)
- Single-cell transcriptomic and immune microenvironment analyses reveal a TIMP1-associated OLFM4⁺ tumor epithelial program linked to colorectal cancer progression and immune evasion. — Transl Oncol, 2026-10-16 (PMID 42887063; literature)
- A multi-omics study integrating single-cell transcriptomics, spatial transcriptomics, and mendelian randomization unveil the implication of TRDMT1 expression in T cells on the immunotherapeutic response and prognosis in breast cancer. — Funct Integr Genomics, 2026-10-21 (PMID 42901998; literature)
- CYP1B1 is a potential target of kaempferol in renal fibrosis: a multi‑omics and single‑cell transcriptomics study. — Bioresour Bioprocess, 2026-10-20 (PMID 42900454; literature)
- Si-scRNA-seq: Enabling ambient-stable single-cell transcriptomics through spatially confined biosilicification. — Proc Natl Acad Sci U S A, 2026-10-23 (PMID 42912787; literature)
- Single-cell landscape of alcohol-related hepatitis reveals serum amyloid a hepatocytes as key drivers of disease pathogenesis. — Hepatology, 2026-10-23 (PMID 42912712; literature)
- Cellular diversity of the developing chick trigeminal ganglion at single-cell resolution. — Dev Dyn, 2026-10-23 (PMID 42924893; literature)
- Single‑cell multi‑omics analysis reveals TGF-β1-RUNX2-mediated matCAF differentiation and its role in remodeling the lymph node metastatic microenvironment in bladder cancer. — Oncogene, 2026-10-23 (PMID 42918833; literature)
- Whole-transcriptome single-cell spatial landscape of instability in human carotid atherosclerosis. — Cardiovasc Res, 2026-10-26 (PMID 42929042; literature)
- Single-Cell Resolution Mapping Reveals Cell Death-Associated Stress Programs and Osteogenic-Chondrogenic Differentiation Imbalance in Subchondral Bone Mesenchymal Stem Cells of Knee Osteoarthritis. — Exp Cell Res, 2026-10-23 (PMID 42918564; literature)
- OSCAR: an omics atlas of paired single-cell ATAC-seq and RNA-seq for decoding cell-specific gene regulation. — Nucleic Acids Res, 2026-10-27 (PMID 42935243; literature)
- Combining Single-Cell Data with Machine Learning Uncovers the Molecular Landscape of Keratoconus. — Exp Eye Res, 2026-10-26 (PMID 42933630; literature)
- Single-Cell RNA sequencing analysis of cellular heterogeneity and microenvironment-driven signaling networks in acute myeloid leukemia. — Leuk Lymphoma, 2026-10-29 (PMID 42958815; literature)
- Integrated Single-Cell and Spatial Transcriptomics Reveal Convergence on a Senescence-Associated B Cell-MIF Signaling Axis in Joint Aging and Osteoarthritis Progression. — Adv Sci (Weinh), 2026-10-29 (PMID 42958787; literature)
What it is
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an amplified nucleotide sample that was derived from a single cell.
Source: National Cancer Institute, NCI Thesaurus 26.09d, C171152. NCI definition, reproduced without modification under CC BY 4.0.
Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Compliance note
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
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