National Cancer Institute (source definition)
Electrospray Ionization
A procedure used in mass spectrometry analysis. Means of delivering nonvolatile analytes into the gas phase for mass analysis. Best used on molecules which are charged in solution or readily accept a charge. Particularly well suited to the analysis of biomolecules. Can be used to probe tertiary structure and non-covalent interactions (from NCSU Mass Spectrometry Facility web site)
Review and references
Automated source check (NCI definition)
2026-10-20
2026-10-28
professional use
References
- NCI Thesaurus 26.09d — Electrospray Ionization (C19363)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C19363. NCI definition, reproduced without modification under CC BY 4.0.
- Application of robotic sheath-flow probe electrospray ionization (sfPESI) to wet and dry agricultural products and insecticides. — Anal Methods, 2026-10-15 (PMID 42695130; literature)
- A sensitive assay for estimation of DM1 fortified with trastuzumab in human serum utilizing positive LC-MS/MS electrospray ionization and its application to clinical study. — Bioanalysis, 2026-10-13 (PMID 42868192; literature)
- Spatial metabolomics based on desorption electrospray ionization-ion mobility-mass spectrometry imaging reveals distinct accumulation patterns and biosynthetic sites of diosgenin-type and pennogenin-type saponins in Paris polyphylla var. yunnanensis. — J Pharm Biomed Anal, 2026-10-05 (PMID 42858480; literature)
- Highly sensitive determination of polyunsaturated fatty acids by permanently charged derivatization-liquid chromatography-electrospray ionization tandem mass spectrometry. — Anal Sci, 2026-10-27 (PMID 42934419; literature)
What it is
A procedure used in mass spectrometry analysis. Means of delivering nonvolatile analytes into the gas phase for mass analysis. Best used on molecules which are charged in solution or readily accept a charge. Particularly well suited to the analysis of biomolecules. Can be used to probe tertiary structure and non-covalent interactions (from NCSU Mass Spectrometry Facility web site)
Source: National Cancer Institute, NCI Thesaurus 26.09d, C19363. NCI definition, reproduced without modification under CC BY 4.0.
Source identity and definition checked automatically on 2026-10-20. No individual clinical interpretation or human reviewer is asserted.
Compliance note
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
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