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Tests

Triple Phosphate Crystal Measurement

The determination of the amount of triple phosphate crystals present in a urine sample.

For professionals

Technology

Selected Reaction Monitoring

A method for collecting tandem mass spectrometry data where an ion of a particular mass is selected in the first stage and a fragmented ion product is selected in the second mass spectrometer stage for detection. Selected reaction monitoring (SRM)-based experiments are generally performed in a triple quadrupole (QqQ) mass spectrometer.

Diagnostic Methods

Article

Clinical Validation of Digital PCR-Based ctDNA Detection for Risk Stratification in Residual Triple-Negative Breast Cancer: TRICIA Trial Results.

Research record from Clin Cancer Res, 2026-04-01. PMID 41662447.

Article

Detection and quantification of 4F-metomidate and its metabolites, metomidate, in human blood and urine by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/MS).

Research record from Leg Med (Tokyo), 2026-08-06. PMID 42570409.

Indicators

Hydroxyproline

A nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.

Article

Identification of Somatic and Germline Mutations Influencing Treatment Outcomes and Disease Susceptibility in Tunisian Triple-Negative Breast Cancer Using Next-Generation Sequencing.

Research record from Br J Biomed Sci, 2026-04-22. PMID 42099507.

Article

Simultaneous detection and quantification of free phenol and three structural isomers of cresol in human blood using gas chromatography-triple quadrupole mass spectrometry and their medical reference value ranges.

Research record from J Anal Toxicol, 2026-04-01. PMID 40910905.

Article

Studies on enzymatic hydrolysis of psilocin-O-glucuronide for screening of psilocin in human urine by liquid chromatography-triple quadrupole tandem mass spectrometry.

Research record from J Anal Toxicol, 2026-06-01. PMID 42203689.

Glossary Term

Transfer RNA

A class of short adaptor RNAs that transfers a specific amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis during translation. Each transfer RNA comprises a three-nucleotide sequence that is complementary to the triplet nucleotide coding sequence of an mRNA, conferring specificity to the amino acid being incorporated into the assembling protein.

Pcr Terms

Article

Triple-modality diagnosis of paucibacillary pulmonary tuberculosis: comparative accuracy of GeneXpert MTB/RIF, TB-DNA PCR, and T-SPOT.TB.

Research record from Front Med (Lausanne), 2026-09-07. PMID 42769177.

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