Technology
Loss of Heterozygosity Analysis
An analysis done to detect monoallelic loss of genes or DNA regions in a diploid cell.
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Technology
An analysis done to detect monoallelic loss of genes or DNA regions in a diploid cell.
Glossary Term
A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.
Article
Research record from Mod Pathol, 2026-10-05. PMID 42833292.
Indicators
This gene plays a role in cell-cell adhesion and loss of function contributes to the progression of many carcinomas.
Article
Research record from Pathol Int, 2026-09-01. PMID 42801547.
Article
Research record from Cytometry B Clin Cytom, 2026-07-05. PMID 42402993.
Glossary Term
A deletion that results in the loss of a DNA segment encompassing an entire gene sequence.
Article
Research record from Transplant Cell Ther, 2026-06-26. PMID 42361982.
Glossary Term
Any transmissible change in the genetic material of an organism, which can result from radiation, viral infection, transposition, treatment with mutagenic chemicals and errors during DNA replication or meiosis. The effects of mutation range from single base changes to loss or gain of complete chromosomes. As many of the simpler alterations to DNA may be repaired, such changes are only heritable once the change is fixed in the DNA by the process of replication. Mutations may be associated with genetic diversity or with pathologies including cancer.
Glossary Term
Nonfunctional DNA sequences that are very similar to the sequences of known genes. Many seem to have arisen as functional gene duplications that subsequently underwent mutation and loss of function. Others are structurally similar to mRNA and seem to have arisen by a reverse transcription event followed by integration into the genome. Some pseudogenes are transcribed and may play a role in regulation of its homologous gene.
Indicators
This gene is involved in cell cycle regulation and the loss of cellular adhesion.