Tests
American Cockroach Antigen IgG4 Antibody Measurement
A measurement of the American cockroach (Periplaneta americana) antigen IgG4 antibody in a biological specimen.
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Tests
A measurement of the American cockroach (Periplaneta americana) antigen IgG4 antibody in a biological specimen.
Tests
A measurement of the Bermuda grass (Cynodon dactylon) pollen IgG4 in a biological specimen.
Tests
A measurement of the birch pollen IgG4 in a biological specimen.
Tests
The determination of the amount of Dermatophagoides pteronyssinus antigen IgG4 antibody present in a sample.
Tests
A measurement of the English plantain (Plantago lanceolata) pollen IgG4 in a biological specimen.
Tests
A measurement of the German cockroach (Blattella germanica) antigen IgG4 antibody in a biological specimen.
Indicators
Along with the immunoglobulin G3 subclass (IgG3), the IgG4 subtype makes up a minor part of circulating antibodies in healthy individuals. The IgG4 core hinge sequence contains 12 amino acids and two interchain disulfide bonds.This subtype has moderate affinity for binding Fc receptors and does not bind complement component C1q. The production of IgG4 can be stimulated following repeated or long-term exposure to antigen. Elevated levels are found in various diseases and infections and can be indicative of an fibroinflammatory syndrome known as IgG4-related disease.
Tests
A measurement of the Mucor racemosus IgG4 in a biological specimen.
Tests
A measurement of the orchard grass (Dactylis glomerata) pollen IgG4 in a biological specimen.
Tests
A measurement of the Penicillium notatum antigen IgG4 antibody in a biological specimen.
Tests
A measurement of the silver birch pollen IgG4 in a biological specimen.
Indicators
Along with the immunoglobulin G4 subclass (IgG4), the IgG3 subtype makes up a minor part of circulating antibodies in healthy individuals. The core hinge sequence contains approximately four times the number of amino acids as the other subclasses; allotypes of IgG3 can have up to 62 hinge residues and up to four interchain disulfide bonds. The increased hinge size for IgG3 increases the separation between the Fc (constant fragment) tail and Fab (antigen binding fragment) arms of antibodies of this subclass. This enhances the relative flexibility of the molecule, which may modulate antigen-binding capacity and immune complex formation, and may increase the affinity for binding to both Fc receptors and complement component C1q.