Tests
Binding Antidrug IgG2 Antibody Measurement
The determination of the antidrug binding IgG2 antibody in a biospecimen.
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Tests
The determination of the antidrug binding IgG2 antibody in a biospecimen.
Indicators
The second most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG2 core hinge sequence contains 12 amino acids and up to four interchain disulfide bonds. This subtype has low affinity for binding both Fc receptors and complement component C1q. The production of this IgG2 is stimulated by exposure to bacterial capsular polysaccharides and other antigenic glycans.
Tests
The determination of the neutralizing cross-reactive antidrug binding IgG2 antibody in a biospecimen.
Indicators
An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli.
Tests
The determination of the amount of immunoglobulin G subclass 2 present in a sample.