Tests
CNS Affecting Drug Measurement
The determination of the amount of any drug that affects the central nervous system (CNS) present in a sample.
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Tests
The determination of the amount of any drug that affects the central nervous system (CNS) present in a sample.
Article
Research record from Front Oncol, 2026-07-17. PMID 42539473.
Glossary Term
A volatile liquid prepared by fermentation of certain carbohydrates. Alcohol acts as a central nervous system (CNS) depressant, a diuretic, and a disinfectant. Although the exact mechanism of CNS depression is unknown, alcohol may act by inhibiting the opening of calcium channels, mediated by the binding of the inhibitory neurotransmitter gamma-amino butyric acid (GABA) to GABA-A receptors, or through inhibitory actions at N-methyl-D-aspartate (NMDA)-type glutamate receptors. Alcohol inhibits the production of antidiuretic hormone, thereby producing diuresis that may lead to dehydration. This agent kills organisms by denaturing their proteins.
Article
Research record from J Natl Compr Canc Netw, 2026-03-31. PMID 41991041.
Article
Research record from Front Cell Infect Microbiol, 2026-07-28. PMID 42582033.
Article
Research record from Int J Infect Dis, 2026-07-12. PMID 42437597.
Article
Research record from Neuro Oncol, 2026-10-12. PMID 42861759.
Indicators
A non-essential, non-polar, non-optical, glucogenic amino acid. Glycine, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential. In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is an important component and precursor for many macromolecules in the cells.
Article
Research record from Adv Anat Pathol, 2026-04-09. PMID 41954087.
Indicators
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. (NCI04)