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Glossary Term
Amplification of several targets in a single reaction using multiple primer pairs, each distinguishable by fluorescent channel or melting profile. Multiplexing raises information per sample but makes channel allocation, dye compatibility, and competition between targets key selection criteria.
Glossary Term
Any transmissible change in the genetic material of an organism, which can result from radiation, viral infection, transposition, treatment with mutagenic chemicals and errors during DNA replication or meiosis. The effects of mutation range from single base changes to loss or gain of complete chromosomes. As many of the simpler alterations to DNA may be repaired, such changes are only heritable once the change is fixed in the DNA by the process of replication. Mutations may be associated with genetic diversity or with pathologies including cancer.
Article
Research record from Mol Cell Oncol, 2026-06-25. PMID 42376597.
Indicators
This gene plays a role in the repair of oxidative DNA damage.
Tests
The determination of cellular MX1 protein expression in a biospecimen.
Indicators
This gene plays a role in hematopoietic cell proliferation and development.
Indicators
This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
Indicators
This gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.
Indicators
This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Indicators
This gene is involved in the modulation of proinflammatory gene expression.
Indicators
This gene plays a regulatory role in muscle contraction and the required ATP hydrolysis.
Tests
The determination of the naive B-lymphocytes in a biospecimen.
