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Glossary Term
A statistical technique which helps in making inference whether three or more samples might come from populations having the same mean; specifically, whether the differences among the samples might be caused by chance variation.
Tests
An anion gap blood test gives a measurement of the acid-base balance (pH balance) in your blood. This lets you know whether your blood is too acidic or not acidic enough. The test also checks for an electrolyte imbalance in your blood. To do the measurement, an anion gap test uses the results of an electrolyte panel or other blood tests that measure your electrolytes.
Indicators
Human ANPEP wild-type allele is located within 15q25-q26 and is approximately 30 kb in length. This allele, which encodes aminopeptidase N protein, is involved in the modulation of peptide hydrolysis and human infection by cytomegalovirus and coronavirus.
Indicators
An antiphospholipid autoantibody that reacts with beta-2-glycoprotein 1, and a member of family of autoantibodies that cause antiphospholipid antibody syndrome and may be found in system lupus erythematosus.
Indicators
A type of antinuclear antibody that specifically targets double stranded DNA; while these antibodies are sometimes detectable in multiple different autoimmune disorders, their presence is generally considered highly specific for systemic lupus erythematosus.
Indicators
An autoantibody that recognizes histidyl-tRNA synthetase, cytoplasmic protein.
Indicators
An antinuclear antibody directed against a 47 kDa RNA-binding protein in the nucleus. They can be associated with Sjogren syndrome and system lupus erythematosus. Maternal anti-La antibody positivity can be associated with neonatal lupus.
Tests
An anti-müllerian hormone (AMH) test measures the amount of AMH in a blood sample. In males, the testicles (or testes), which are glands that make sperm and hormones, make AMH. In females, the ovaries, which are glands that store and develop eggs and make hormones, make AMH.
Indicators
An antinuclear antibody directed against U1 snRNP, that is strongly associated with mixed connective tissue disease and commonly detected in lupus.
Indicators
An antinuclear antibody directed against 52 or 60 kDa RNA-binding proteins in the nucleus. They can be associated with multiple autoimmune disorders, primarily Sjogren syndrome and system lupus erythematosus. Maternal anti-Ro antibody positivity can be associated with neonatal lupus.
Indicators
An antinuclear antibody directed against small nuclear ribonucleoproteins (snRNPs), that is highly specific, but has poor sensitivity for systemic lupus erythematosus (SLE). Presence of anti-Sm antibodies are associated with central nervous system, kidney, lung and cardiac involvement in SLE, but are not indicative of disease activity.
Glossary Term
A type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen.
