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Article

KRAS Mutation Detection by Real-Time and Digital PCR in Tumor Tissue and Plasma and Its Association with Survival in Stage II-IV Colorectal Cancer: A Kazakhstan Cohort Study.

Research record from Genes (Basel), 2026-07-31. PMID 42650100.

Glossary Term

Loss of Heterozygosity

A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.

Pcr Terms

Indicators

MEN1 Gene

This gene is involved in transcriptional regulation and has tumor suppressor activity.

Article

Multiplex RT-PCR-Based Sequencing Assay to Detect Kidney Cancer-Specific Splice Variants in Tumor Tissues and Plasma Cell-Free RNAs.

Research record from Mol Diagn Ther, 2026-07-06. PMID 42410176.

Indicators

MYC Gene

This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.

Indicators

MYCN Gene

This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Article

Nanoplate based digital PCR assay for effective quantification of plasma HPV circulating tumor DNA.

Research record from NPJ Precis Oncol, 2026-04-21. PMID 42014803.

Article

Next-Generation Sequencing of Circulating Tumor DNA for Precision Medicine in Patients with Advanced Biliary Tract Cancers.

Research record from Clin Cancer Res, 2026-10-01. PMID 42223536.

Article

Next-generation sequencing-based characterization of BRCA1/2 variants across multiple tumor types in Vietnamese patients.

Research record from BMC Cancer, 2026-07-17. PMID 42464142.

Article

Next-Generation Sequencing-Based Molecular Profiling and Management of Advanced Solid Tumors: A Real-World Experience in a Community-Based Academic Cancer Center.

Research record from Cancer Med, 2026-10-01. PMID 42839555.

Tests

PDL1 (Immunotherapy) Tests

A PD-L1 test uses a sample of cancerous tumor tissue to measure how much of a protein called programmed-death ligand 1 (PD-L1) is found on the cancer cells. Normally, PD-L1 is found on certain healthy cells. It helps keep your immune system from attacking healthy tissue by acting as a kind of "brake" on your immune system cells (called T-cells). However, in some cancers, PD-L1 keeps your immune system from attacking cancerous cells.

For everyone & professionals

Article

Performance validation and clinical concordance of a novel fully automated immunoassay system for five tumor markers: A comparative study with an international reference platform.

Research record from Pract Lab Med, 2026-05-07. PMID 42200146.

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