Indicators
EED Gene
This gene plays a role in the negative regulation of transcription.
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Indicators
This gene plays a role in the negative regulation of transcription.
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This gene is involved in the epidermal growth factor signal transduction pathway.
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This gene is involved in calcium-independent cellular adhesion and in the regulation of immune responses.
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This gene plays a role in cellular proliferation and is involved in the oncogenic process through amplification and/or overexpression in several cancers.
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This gene is involved in signal transduction pathways that result in cellular proliferation or differentiation. The gene has also been associated with numerous cancers.
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Erythropoietin (193 aa, ~21 kDa) is encoded by the human EPO gene. This protein plays a role in both erythropoiesis and the maintenance of red blood cell volume.
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The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.
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A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)
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This gene plays a role in the coagulation cascade.
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This gene may be involved in the mediation of DNA repair.
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This gene is involved in the regulation of meiosis, DNA repair and the cell cycle.
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This gene plays a role in the regulation of both DNA repair and protein localization.