Indicator Explainer
Estradiol
The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.
This page explains what the indicator is and how results are interpreted in general terms. Reference ranges depend on the laboratory, the method, and your own situation — no single “normal value” applies to everyone. This page is health information, not a diagnosis. For symptoms, treatment, or urgent concerns, contact a healthcare professional.
When it is tested
Source: National Cancer Institute, NCI Thesaurus 26.09d, C2295. NCI definition, reproduced without modification under CC BY 4.0. Source identity and definition checked automatically on 2026-10-18. No individual clinical interpretation or human reviewer is asserted.
Reading results
Reference intervals and interpretation depend on the laboratory, specimen, method and clinical context. This source definition is educational information; it does not establish a diagnosis, product approval or suitability for an individual.
Also Known As
References
- NCI Thesaurus 26.09d — Estradiol (C2295)
- Source: National Cancer Institute, NCI Thesaurus 26.09d, C2295. NCI definition, reproduced without modification under CC BY 4.0.
- Estradiol-dependent memory and hippocampal spine remodeling require proteasomal protein degradation. — J Neurosci, 2026-10-09 (PMID 42855312; literature)
- Advanced Periovulatory Follicle Progression in Beef Heifers: Association with Higher Estrous Associated Temperatures (H.E.A.T.) and Estrous Activity on Intrafollicular Levels of Estradiol and Metabolites. — J Anim Sci, 2026-10-05 (PMID 42832305; literature)