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Indicators
A heterotrimeric protein complex composed of complement component 8 (C8) chains alpha, beta and gamma. The alpha and gamma chains form a disulfide-linked dimer that is noncovalently associated with the beta chain. C8 inserts itself into target cell membranes following formation of the C5b-6-7 complex and then recruits 10-16 molecules of C9 to complete the formation of the membrane attack complex.
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Complement component C9 (559 aa, ~63 kDa) is encoded by the human C9 gene. This protein plays a role in complement-mediated bacterial cell lysis.
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Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.
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This gene plays a role in transcriptional regulation and in NF-kappa B signal transduction.
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This gene plays an inhibitory role in cell survival and proliferation.
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This gene is involved in signal transduction and regulation of transcription.
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This gene plays a role in protein degradation and cell cycle arrest.
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This gene is involved in the mediation of viral entry into cells and cellular migration and chemotaxis.
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A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)
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This gene plays a role in signal transduction, regulation of transcription and enhancement of apoptosis.
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This gene may play a role in RNA splicing and tumor suppression.
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This gene is involved in the RNA interference pathway.
