Indicators
MITF Gene
This gene is involved in transcriptional promotion in melanocytes.
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Indicators
This gene is involved in transcriptional promotion in melanocytes.
Indicators
This gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.
Indicators
This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Indicators
This gene plays a role in transcriptional regulation.
Indicators
This gene plays a role in thyroid gene transcription.
Glossary Term
Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.
Indicators
This gene is involved in the transcriptional regulation of target genes. It plays a role in B-cell differentiation, neural development and spermatogenesis.
Indicators
This gene plays a role in transcriptional regulation.
Indicators
This gene is involved in repression of transcription. It plays a role in the formation of pre-plasma memory B cells and immunoglobulin-secreting plasma cells.
Glossary Term
A DNA sequence at which RNA polymerase binds and initiates transcription.
Glossary Term
Nonfunctional DNA sequences that are very similar to the sequences of known genes. Many seem to have arisen as functional gene duplications that subsequently underwent mutation and loss of function. Others are structurally similar to mRNA and seem to have arisen by a reverse transcription event followed by integration into the genome. Some pseudogenes are transcribed and may play a role in regulation of its homologous gene.
Indicators
This gene plays a role in the regulation of cell signaling. It is involved in cell migration, metabolic control, mitogenic activation and gene transcription.