Indicators
SMO Gene
This gene plays a role in G protein-coupled receptor signal transduction and sonic hedgehog pathway activation.
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Indicators
This gene plays a role in G protein-coupled receptor signal transduction and sonic hedgehog pathway activation.
Indicators
This gene plays a role in signal transduction and activation of transcription. It is involved in regulation of both apoptosis and cell growth.
Indicators
This gene is involved in signal transduction and activation of transcription. It plays a role in the immune response via stimulation of T-cell proliferation.
Indicators
Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways.
Indicators
This gene plays a role in signal transduction and cell cycle control. It is involved in cell adhesion, differentiation, growth and migration.
Indicators
Thyroid-stimulating hormone — the pituitary signal that regulates the thyroid and the usual first test of thyroid function.
Tests
A measurement of the tumor associated calcium signal transducer 2 in a sample.
Glossary Term
Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.