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A measurement of the clotting time of plasma recalcified in the presence of excess tissue thromboplastin; it is a measure of the extrinsic pathway of coagulation. It is used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage and vitamin K status. Factors measured are fibrinogen, prothrombin, and factors V, VII, and X.
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Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.
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This gene plays a role in transcriptional regulation and cytogenetic aberrations are associated with several leukemias.
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Somatostatin (116 aa, ~13 kDa) is encoded by the human SST gene. This protein plays a role in the downregulation of somatotropin release.
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This gene is involved in guanine nucleotide exchange.
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This gene is involved in transcriptional regulation and cell cycle progression regulation.
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This gene plays a role in cellular proliferation and mitogenic responses.
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Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways.
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Tumor necrosis factor (233 aa, ~26 kDa) is encoded by the human TNF gene. This protein is involved in the induction of cytokine expression, the stimulation of cell proliferation and the positive regulation of cell differentiation.
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Tumor necrosis factor receptor superfamily member 11B (401 aa, ~46 kDa) is encoded by the human TNFRSF11B gene. This protein plays a role in the negative regulation of both osteoblast differentiation and bone resorption.
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This gene is involved in the splicing of mRNA.
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This gene is involved in RNA binding and pre-mRNA splicing.
