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Tests
The determination of the ratio of the concentration of interleukin-2 receptor to the number of lymphocytes present in a biological sample. The measurement may be expressed as a ratio or percentage.
Indicators
A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.
Indicators
Interleukin-4 (153 aa, ~17 kDa) is encoded by the human IL4 gene. This protein is involved in the regulation of the expression of class II MHC molecules, Fc receptors and cell surface-bound immunoglobulins.
Tests
The determination of the amount of interleukin-4 receptor subunit alpha in a sample.
Indicators
Interleukin-5 (134 aa, ~15 kDa) is encoded by the human IL5 gene. This protein plays a role in the growth and differentiation of both B-cells and eosinophils.
Indicators
Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.
Tests
An immunoassay that is used to determine the amount of soluble interleukin-2 receptor subunit alpha in a patient serum sample. High levels of the soluble form of the receptor can be indicative of hematological malignancies and other neoplastic disorders.
Tests
The determination of the amount of soluble interleukin 2 receptor activity present in a sample.
