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Glossary Term
A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.
Glossary Term
A statistical method to test if observations are significant or due to chance. It proposes that no statistical significance exists in a set of given observations and attempts to show that no variation exists between variables or that a single variable is no different than its mean. It is presumed to be true until statistical evidence nullifies it for an alternative hypothesis.
Glossary Term
The difference between the lowest and highest numerical values; the limits or scale of variation.
Glossary Term
Complementary precision measures: repeatability is variation under the same conditions (same operator, equipment, short interval); reproducibility is variation across conditions — different days, operators, lots, or laboratories.
Glossary Term
A variation of a single nucleotide at a specific location of the genome due to base substitution, present at an appreciable frequency between individuals of a single interbreeding population.
Glossary Term
A variation of a single nucleotide at a specific location of the genome due to base substitution, which is found at any frequency in the population.
Glossary Term
A measure of the range of values in a set of numbers. Standard deviation is a statistic used as a measure of the dispersion or variation in a distribution, equal to the square root of the arithmetic mean of the squares of the deviations from the arithmetic mean.
Technology
Check PCR instrument compatibility by fluorescence channels, reaction format support, software fit and validation effort.
Technology
Check assay-to-instrument fit by fluorescence channels, reaction format and software compatibility across installed PCR platforms.
Technology
Evaluate limit of detection, precision, repeatability and evidence strength for PCR product validation, tenders and procurement review.
Article
Research record from Diagnostics (Basel), 2026-07-10. PMID 42510022.
Article
Research record from Cytometry A, 2026-06-26. PMID 42363016.
