Technology
Multiplex PCR Guide: Panel Design, Use Cases & Performance Trade-offs
Learn how multiplex PCR balances panel breadth, sensitivity, cross-reactivity and instrument compatibility across clinical applications.
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Technology
Learn how multiplex PCR balances panel breadth, sensitivity, cross-reactivity and instrument compatibility across clinical applications.
Indicators
An antinuclear antibody directed against small nuclear ribonucleoproteins (snRNPs), that is highly specific, but has poor sensitivity for systemic lupus erythematosus (SLE). Presence of anti-Sm antibodies are associated with central nervous system, kidney, lung and cardiac involvement in SLE, but are not indicative of disease activity.
Indicators
This gene is involved in nucleotide excision repair and corrects sensitivity to UV radiation and defective nucleotide excision repair in xeroderma pigmentosum cells of complementation group D.
Indicators
High-sensitivity C-reactive protein — an inflammation marker also used, in context, in cardiovascular risk assessment.
Article
Validation burden grows faster than target count on multiplex panels: cross-reactivity scope, sensitivity balancing, and sample-size planning for rare targets.
Indicators
A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.
Technology
Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times.
Tests
An acute-phase protein that rises rapidly during inflammation; used to detect and monitor infection and inflammatory disease.
Tests
Blood proteins released when heart muscle is injured; the primary laboratory marker in the evaluation of possible acute myocardial infarction.
Tests
A clotting test measuring the extrinsic pathway, standardised internationally as INR to monitor vitamin K antagonist therapy and assess bleeding risk.