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Glossary Term

Base Excision Repair

Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.

Pcr Terms

Article

Cell-free DNA metagenomic next generation sequencing for the diagnosis of infectious diseases: a retrospective assessment of clinical utility in a tertiary and quaternary care facility.

Research record from Front Microbiol, 2026-08-11. PMID 42643498.

Article

Clinical efficacy of plasma cell-free DNA metagenomic next-generation sequencing in diagnosing bloodstream infections.

Research record from BMC Infect Dis, 2026-03-21. PMID 41864933.

Article

Clinical impact of plasma cell-free DNA metagenomic next-generation sequencing testing in neonatal and infant populations.

Research record from Antimicrob Steward Healthc Epidemiol, 2026-07-06. PMID 42422873.

Article

Comparative diagnostic performance of plasma microbial cell-free DNA sequencing versus amplicon-based blood next-generation sequencing in suspected bloodstream or endovascular infection: a single-center study.

Research record from Antimicrob Steward Healthc Epidemiol, 2026-03-27. PMID 42038596.

Article

Comprehensive Assessment of Flow Cytometry Light Chains: Qualitative and Quantitative Evaluation Using Serum Protein Immunofixation and Free Light Chain Analysis.

Research record from Int J Lab Hematol, 2026-07-10. PMID 42432831.

Article

Correction to "Label-Free Typing of Colorectal Cancer by Optical Time-Stretch Imaging Flow Cytometry With Multi-Instance Learning".

Research record from J Biophotonics, 2026-04-01. PMID 41942141.

Article

Culture-free resistance detection: where rapid molecular AMR markers fit in stewardship

Where rapid molecular AMR markers fit in antimicrobial stewardship: isolation decisions, de-escalation, the limits of single markers, and procurement checks before you buy.

Article

Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing.

Research record from Sci Rep, 2026-03-11. PMID 41813780.

Article

Diagnosis of histoplasmosis by next-generation sequencing of microbial cell-free DNA in Texas.

Research record from Antimicrob Steward Healthc Epidemiol, 2026-06-01. PMID 42238734.

Article

Disseminated Strongyloides stercoralis infection diagnosed by metagenomic next-generation sequencing of a cell-free DNA blood sample in a patient with hematologic malignancy in Germany: A case report.

Research record from Int J Infect Dis, 2026-03-30. PMID 41921901.

Tests

Double Marker Test

A blood test done near the end of the first trimester of pregnancy to screen for common chromosomal defects. This test screens for blood levels of both free beta-human chorionic gonadotrophin (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A) and can detect trisomies of chromosomes 21 (Down's syndrome), chromosome 18 (Edward's syndrome), and chromosome 13 (Patau's syndrome).

For professionals

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