Indicators
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
Indicators
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune responses.
Tests
The determination of the ratio of the concentration of interleukin-2 receptor to the number of lymphocytes present in a biological sample. The measurement may be expressed as a ratio or percentage.
For professionals
Indicators
A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.
Indicators
Interleukin-4 (153 aa, ~17 kDa) is encoded by the human IL4 gene. This protein is involved in the regulation of the expression of class II MHC molecules, Fc receptors and cell surface-bound immunoglobulins.
Indicators
Interleukin-6 (212 aa, ~24 kDa) is encoded by the human IL6 gene. This protein is involved in signaling affecting a wide variety of cell types including monocytes, lymphocytes, hepatocytes and nerve cells.
Indicators
Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.
Tests
The determination of the ratio of the intermediate monocytes to a subpopulation of lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.
For professionals
Tests
The determination of the intermediate natural killer cells to a sub-population of lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.
For professionals
Tests
The determination of the ratio of a sub-population of invariant natural killer T-lymphocytes to a sub-population of invariant natural killer T-lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.
For professionals
Tests
The determination of the ratio of the invariant natural killer T-lymphocytes to total natural killer T-lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.
For professionals
Tests
The determination of the number of large lymphocytes present in a sample.
For professionals
